What is Tirzepatide and how does it work for weight loss? June 17, 2024 | Dr. Jamal Bullocks Tirzepatide is a prescription injectable medication for chronic weight management. Similar to Semaglutide, it targets hormones that regulate appetite and gut motility, promoting feelings of fullness and reducing hunger. Studies suggest that Tirzepatide may be even more effective for weight loss compared to Semaglutide.